Correction for Haag et al., Evolution of a morphological novelty occurred before genome compaction in a lineage of extreme parasites.

نویسندگان

  • Karen L Haag
  • Timothy Y James
  • Jean-François Pombert
  • Ronny Larsson
  • Tobias M M Schaer
  • Dominik Refardt
  • Dieter Ebert
چکیده

Intracellular parasitism results in extreme adaptations, whose evolutionary history is difficult to understand, because the parasites and their known free-living relatives are so divergent from one another. Microsporidia are intracellular parasites of humans and other animals, which evolved highly specialized morphological structures, but also extreme physiologic and genomic simplification. They are suggested to be an early-diverging branch on the fungal tree, but comparisons to other species are difficult because their rates of molecular evolution are exceptionally high. Mitochondria in microsporidia have degenerated into organelles called mitosomes, which have lost a genome and the ability to produce ATP. Here we describe a gut parasite of the crustacean Daphnia that despite having remarkable morphological similarity to the microsporidia, has retained genomic features of its fungal ancestors. This parasite, which we name Mitosporidium daphniae gen. et sp. nov., possesses a mitochondrial genome including genes for oxidative phosphorylation, yet a spore stage with a highly specialized infection apparatus--the polar tube--uniquely known only from microsporidia. Phylogenomics places M. daphniae at the root of the microsporidia. A comparative genomic analysis suggests that the reduction in energy metabolism, a prominent feature of microsporidian evolution, was preceded by a reduction in the machinery controlling cell cycle, DNA recombination, repair, and gene expression. These data show that the morphological features unique to M. daphniae and other microsporidia were already present before the lineage evolved the extreme host metabolic dependence and loss of mitochondrial respiration for which microsporidia are well known.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evolution of a morphological novelty occurred before genome compaction in a lineage of extreme parasites

Zoological Institute, Basel University, 4051 Basel, Switzerland; Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, 91501-970 RS, Brazil; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109; Department of Biological and Chemical Sciences, Illinois Institute of Technology, Chicago, IL 60616; Department of Biology, University of ...

متن کامل

The Ordospora colligata Genome: Evolution of Extreme Reduction in Microsporidia and Host-To-Parasite Horizontal Gene Transfer

UNLABELLED Microsporidia are a group of obligate intracellular parasites that are best known for their unique infection mechanism and their unparalleled levels of genomic reduction and compaction. We sequenced the genome of Ordospora colligata, a gut parasite of the microcrustacean Daphnia sp. and the closest known relative to the microsporidia characterized by the most extreme genomic reductio...

متن کامل

O-44: Characterisation of Monotreme CaseinsReveals Lineage Specific Expansion of an AncestralCasein Locus in Mammals

Background: One important reproductive characteristic of Mammals is the production of milk to nurse the neonate. In order to better understand the evolution of milk we have investigated gene expression in milk cells from monotremes which are the most ancient representative of the mammalian lineage. Materials and Methods: Using a milk cell cDNA sequencing approach we characterise milk protein se...

متن کامل

بررسی رابطه بین توده‌واری سرمایه‌گذاران و نوسان‌پذیری: شواهدی از بورس اوراق بهادار تهران

This study examines the effect of Herding in different states (low, high and extreme volatility) in Tehran Stock Exchange during the years 2009-2013 using Chang et al (2000) and Balcilar et al (2013) models. In this survey herding are tested under 3 market regimes in selected industries: Cement, Chemical, Pharmaceutical and Investment. The results don't show evidence of herding in 4 industries...

متن کامل

Critique of Manuscript Correction/ Among Fire and Water: A Critique of the Last Correction of Seir Al-Ebad Ela Al-Mā'd Masnavi, Maryam Mosharraf

Sanayi Ghaznavi’s Seir Al-Ebad Ela Al-Mā'd is one of the most famous works in the field of Persian pedagogic literature. This remarkable Masnavi has been considered for many years among the most important sixth-century. However, due to some difficulties in reading the verses, there are still some vague points in this Masnavi. This paper attempts to refer to some of these difficulties in the tex...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 111 43  شماره 

صفحات  -

تاریخ انتشار 2014